July/August 1996
Number 131
A Publication of The Bioelectromagnetics Society
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HANSSON MILD REVIEWS THE ACCOMPLISHMENTS OF THE SOCIETY
AND LOOKS TO THE FUTURE
[At the Eighteenth Annual Business Meeting in Victoria, B.C., Canada,
June 12, 1996, outgoing BEMS President Kjell Hansson Mild, acknowledged
the positive happenings of the past year and shared his vision of what
the future might bring. The text of his speech appears below.]
It gives me great pleasure to talk to you at this Annual Meeting, looking
back at the year that has just past. It has been a year with several positive
happenings and I will comment on some of them.
Looking back over the past year.....During this past year we came to
an agreement with the European Bioelectromagnetics Association (EBEA) about
the journal Bioelectromagnetics. As you surely noticed, Bioelectromagnetics
is now the joint journal for three societies: BEMS, the Society for Physical
Regulation in Biology and Medicine (SPRBM) and EBEA. The negotiations with
EBEA started in 1989 and in the autumn of 1995 at an EBEA Board meeting
held in Kuopio, Finland, EBEA accepted the terms and signed the agreement.
This new situation led to the addition of two new Associate Editors
from Europe -- Dr. Alessandro Chiabrera of Italy and Dr. Peter Semm of
Germany. This also entailed my stepping down as Associate Editor, a job
that has been interesting and rewarding. I will continue to work with Bioelectromagnetics
as a member of the Editorial Board.
Although we continue to face the challenge of a faster publication time,
you should be aware that we are all trying to reduce the time from submittance
to printing as much as possible. However, there are several links in the
chain from manuscript to printed paper, and we can all contribute here,
both as reviewers and as authors. Please, when you are asked to review
a paper, if you do not think you can do it within the given time, return
the paper immediately. Do not wait until six months have elapsed and then
admit you did not have time. Authors are reminded to read and follow the
instructions -- this also helps quicken the process. Finally, return revisions
as quickly as possible, or at least tell the Editors when they can expect
your revision.
Although I point out the challenges we face with our journal, the overall
picture is very positive. We have a very good journal and I am confident
that it will continue to be so in the future. Thanks for a great year,
Editor-in-Chief, Ben Greenebaum, and best of luck for the future.
The second thing of importance that happened this year was our official
statement on ELF electromagnetic fields and biological effects. Although
the accomplishment of this has been the work of the Board, the momentum
behind it has been our Past President, Dr. James Lin. Jim has been the
principal editor, debating and incorporating suggestions for wordings --
all the "ifs," "buts," and "howevers." This is the first statement made
by The Bioelectromagnetics Society and it has been a new experience to
all of us. We on the Board felt that such a statement was needed, and looking
at it now we think we have a balanced statement. Thank you, Jim.
The third thing I would like to bring up is our Homepage on the Internet
[http://www.bioelectromagnetics.org/index.html].
We have been discussing this for at least two years and now it is a reality
because of the efforts of Dr. Jeff Saffer at Battelle. Thanks, Jeff, for
work well done. We also express our thanks to Battelle for giving up space
on their server for this purpose. For several years, I have been asking
to have the abstracts a few weeks in advance of the annual meeting -- and
as with our Homepage this has become a reality. Hopefully, next year we
will be able to have them available on the Homepage even earlier so that
we can all prepare for the Annual Meeting from our homes. That way we should
be more inclined to go into discussion while at the meeting and not have
to spend our evenings reading the next day's abstracts. We will see what
happens next year.
It is also a great pleasure to see the BEMS flag being shown in meetings
other than our Annual Meeting. In February 1996, the local Washington,
DC BEMS Chapter arranged a one-day workshop on EMF issues. The attendance
was approximately 50 people. At the Radiation Research Society (RRS) meeting
in April, 1996, we were also present. Anticipating that some of the talks
at the RRS meeting might miscredit bioelectromagnetics research, Professor
Abe Liboff attended to provide a balance to any negative statements that
might arise. We thank Abe for taking this assignment so quickly and doing
a fine job. Next year, BEMS is co-sponsoring a workshop at the International
Physiological Society Congress in St. Petersburg, Russia. For further information
about this workshop you may talk to me during this meeting or write or
call later.
It has also been a pleasure to head your Board and to work with a group
of dedicated, hard working and cooperative Officers and Board members.
Some of them are retiring from their positions today. Let us recognize
Stuart Allen, Lee Rosen, Jeffrey Saffer, and Jan Walleczek. Our Past President,
Jim Lin, has also finished his term and his contributions will be missed.
Our Society is continuing to grow. Currently we have about 700 members
who have paid their dues for 1996. Last year the membership count was 776
- from 34 countries. The Society management has this year, as every other
year, been handled excellently by W/L Associates. Dr. Bill Wisecup and
his coworkers have been taking care of all things -- from the small to
the major issues -- that are necessary to manage a society smoothly. Although
from an individual member basis, we are not always aware of the extent
of work involved, let me assure you that they have their hands full. As
always they come up with excellent arrangements for the Annual Meeting
- as we are witnessing here in Victoria. There is hard work behind making
a meeting of this size successful - and the devil is in the details. My
thanks to Bill and his coworkers.
Looking to the future.....Finally, I am going to do some crystal gazing
to see what the future might bring. I see radio waves with 900 and 1800
MHz, and people holding small devices to their ears and talking - talking
wherever they are. Although we still have quite some way to go before we
can say that we understand the ELF area, many of us will be engaged in
research concerning mobile phones and the possible health effects associated
with the use of these phones. Why? First there will be an enormous increase
in the number of users of phones, and thus also the number of individuals
exposed. Since we do not have all the answers regarding health and weak
field effects, there is an important and immediate need to continue the
research efforts to find answers. Research money will be available for
some time to come. In Europe the EU is talking about setting up a research
program of the order of 50 million ECU (~ 60 million U.S. dollars). This
program will be open world wide and not just restricted to Europe. So,
you are welcome to join.
Next, I see more and more people in the laboratories measuring the DC
field in experimental set-ups. Very few papers will be published about
ELF research without a measurement of the DC field in the laboratory. I
also see more and more of the prudent avoidance strategy being applied
as well by manufacturers of electrical appliances and the power companies
as they build new lines and make electrical installations. Finally, I can
see work being done on the use of electromagnetic fields in medicine --
fields from DC to daylight -- and this work will include both diagnostic
and therapeutic applications.
With this, I thank you for your attention. It has been an honor to serve
as your President.
Kjell Hansson Mild
National Institute for Working Life
P. O. Box 7654
S-907 13 Ume, Sweden
Tel: +46 90 16 50 98
Fax: +46 90 16 65 08
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BEMS PRESIDENTS' LETTER GOES TO CONGRESS FOLLOWING STRONG
URGING FROM MEMBERS
[Following the strong urging of the membership at the Annual Meeting
in Victoria, B.C., Canada, the Present, Immediate Past, and Future Presidents
of the Society, Drs. Richard Luben, Kjell Hansson Mild, and Martin Blank
sent the letter which appears below to key members of the Senate and House
Authorization and Appropriations Committees, the Office of Management and
Budget, and the Office of Science and Technology Policy. The letter was
sent in June 1996.]
Public concern continues to grow about possible connections between
exposure to electric and magnetic fields and such diseases as childhood
leukemia, breast cancer, and Alzheimer's Disease. At the same time, daily
exposure of the public to electric and magnetic fields is increasing rapidly
due to new electronic and communications technology, more use of electric
power, and new medical applications of electric and magnetic fields. As
leaders of the largest international scientific society studying biological
effects of electric and magnetic fields, we are concerned about a potential
decline in research in this area, due in part to public statements by those
who we believe are lacking in the requisite multidisciplinary expertise.
The biological processes involved in human diseases are complex and
multifaceted. Moreover, electric and magnetic fields, unlike many other
environmental agents, are not characterized by a single quantity but involve
many different factors. Proper approaches to such complex scientific questions
can be achieved only by a multidisciplinary collaboration of biologists,
physicians, engineers and biophysicists. A wealth of published, peer-reviewed
scientific evidence indicates that exposure to different combinations of
electric and magnetic fields consistently affects biological systems in
the living body as well as in laboratories, including:
-
Altering the function of nerve cells.
-
Changing the density and healing rate of bone.
-
Disturbing the balance of important hormones.
-
Changing the growth rate and drug sensitivity of cancer cells.
-
Modifying the immune system's ability to fight disease.
-
Altering the heart rate.
There is a potential for benefits from these fields as well as the possibility
of adverse public health consequences. Understanding their biological effects
may allow us to increase the benefits as well as mitigate the possible
hazards. But these processes cannot be well understood without further
research.
Major strides have been made in the past 20 years of research in this
area. The program has only recently expanded to a critical mass of interdisciplinary
and multi-laboratory effort that, in our opinion, must be continued. In
this still emerging area of scientific research, controversy about reported
results is a natural and healthy part of the scientific process. Such controversy
should not be the basis for discarding programs of research before the
important questions are answered conclusively.
We believe it is essential that research in this area be continued.
Without U.S. government funding, the remaining available sources of funds
are too limited, too focused by discipline, and may in some cases carry
questions of bias. The governments of other industrialized countries such
as Sweden, Japan, Germany, and Norway are presently spending significant
amounts of money to further research in this area. But without US leadership,
the task of determining the potential health risks and benefits involved
in the distribution and use of electric and magnetic energy will be difficult
to complete.
We are also concerned that international standards may be imposed before
adequate scientific knowledge is available. Failure to continue this research
could ultimately result in extensive costs to the energy and communications
industries, both in litigation and product development.
Public concern can be reduced only when the issues and questions are
resolved by careful research. We ask that you take these views into account
when making decisions regarding the future of research into the effects
of electric and magnetic fields. The undersigned will be happy to confer
with you in detail or provide any further information you may need in order
to make an informed decision.
Richard A. Luben, BEMS President, 1996-97
Kjell Hansson Mild, BEMS Past President, 1995-96
Martin Blank, BEMS President-Elect, 1997-98
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BLANK ELECTED VICE PRESIDENT (PRESIDENT ELECT)
At the Eighteenth Annual Business Meeting of BEMS which took place in Victoria,
B.C., Canada, Wednesday, June 12, 1996, it was announced that Dr. Martin
Blank, Columbia University, was elected Vice President (President Elect).
Other newly elected Board Members were:
Martin Blank Vice President (President Elect)
Craig Byus Biological/Medical Sciences
Henry Lai Biological/Medical Sciences
Frank Barnes Engineering/Physical Sciences
Gregory Lotz At Large
Retiring members of the Board include: Stuart Allen, James Lin, Lee
Rosen, Jeffrey Saffer, and Jan Walleczek.
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1996-1997 BEMS Officers and Board
EXECUTIVE COMMITTEE
Richard Luben - President
Martin Blank - Vice President/President Elect
Robert Liburdy - Secretary/Treasurer
Ben Greenebaum - Editor-in-Chief
Kjell Hansson Mild - Past President
DIRECTORS
Paul GaileyvEng./Physical Sciences
Janie Blanchard - Eng./Physical Sciences
Frank Barnes - Eng./Physical Sciences
Raphael Lee - Bio./Medical Sciences
Ewa Czerska - Bio./Medical Sciences
Eugene Goodman - Bio./Medical Sciences
Arthur Rosen - Bio./Medical Sciences
Craig Byus - Bio./Medical Sciences
Henry Lai - Bio./Medical Sciences
Indira Nair - At Large
Jukka Juutilainen - At Large
Gregory Lotz - At Large
EX OFFICIO
Carol Jordan Evans - Newsletter Editor
Mary Ellen O'Connor - Newsletter Editor
William G. Wisecup - Executive Director
Raphael Lee - BES Liaison
Ferdinando Bersani - EBEA Liaison
Raphael Lee - SPRBM Liaison
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NEW EDITOR OF NEWSLETTER
I am pleased to report that effective with issue number 133 (November/December
1996) of the Newsletter, the Society will have a new Newsletter editor.
My involvement with the Newsletter began in 1983, but pressure of other
activities forces me to relinquish the role. The Bioelectromagnetics Society
(BEMS) is very fortunate in securing Dr. Mary Ellen O'Connor as the new
editor. Mary Ellen has served as the President of BEMS from 1992-1993,
has been a member of the Board of Directors, is committed to the goals
of the Society and is supremely able to carry the Newsletter to new heights.
I am sure that under her able editorship, your Newsletter will go from
strength to strength. Mary Ellen may be reached at: University of Tulsa,
Psychology Department, 600 S College, Tulsa, OK 74104-3189 (Tel: 918-631-2838;
Fax: 918-631-2833; Email: OCONNORME@centum.utulsa.edu).
It has been an honor to serve the Society.
Carol Jordan Evans
Newsletter Editor
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BES JOURNAL TO BE OFFERED TO BEMS MEMBERS AT REDUCED
RATES
Dr. Martin Blank of the Bioelectrochemical Society (BES) has informed the
Board of Directors in a letter dated November 24, 1995, that Elsevier,
the publisher of the BES journal Bioelectrochemistry and Bioenergetics,
plans to offer reduced subscription rates to members of BEMS. The subscription
rates would be the same as those offered to BES members.
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TENFORDE REPORTS ON NCRP PROGRAM ON EMF AT BEMS '96
[On June 14, 1996, at the Annual BEMS Meeting in Victoria, B.C. Canada,
Dr. Thomas S. Tenforde, Health Division, Battelle Pacific Northwest Laboratories,
Richland, Washington, presented a paper on the National Council on Radiation
Protection and Measurement's (NCRP) program on nonionizing electromagnetic
fields. A synopsis of the paper is presented below.]
The History and Organization of NCRP...The National Council on
Radiation Protection and Measurements (NCRP) was formed by Congress in
1964 as a non-government, non-profit organization with the charter to assess
effects of radiation on human health and the environment, and to recommend
exposure guidelines. The Council consists of 75 members, representing a
broad range of expertise in radiation biology, physics, measurement technology,
epidemiology, and public policy. Members serve six-year terms, with the
possibility of renewal.
Officers include the President (C. B. Meinhold), Vice President (S.
J. Adelstein), Secretary/Treasurer (W. R. Ney), Assistant Secretary (C.
D. Hobelman), and Assistant Treasurer (J. F. Berg). Ten members of the
Council are elected to the Board of Directors, and nine members serve as
Scientific Vice Presidents coordinating major areas of NCRP report activities.
The NCRP has 50 active committees. A total of 122 scientific reports have
been published by the NCRP as well as numerous commentaries, statements,
and proceedings of annual meetings.
SC89 Charter... The NCRP has undertaken several major report
activities related to the possible human health effects of nonionizing
electromagnetic fields. These activities are coordinated by an "umbrella
committee," designated as NCRP Scientific Committee 89. Its charter is
to identify issues and provide coordination and oversight for NCRP report
activities related to occupational, medical, and public exposures to nonionizing
electromagnetic fields with frequencies from 0 to ~ 2 x 1015 Hz (DC to
deep ultraviolet region of the spectrum), and to ultrasound. Areas considered
under the charter include: dosimetry and exposure assessment (both theoretical
and applied aspects); mechanisms of interaction with biological systems,
including humans; biological responses and human health effects; recommendations
on acceptable exposure levels in occupational, medical, and public environments;
and procedures for mitigation of exposure in public and occupational settings.
SC89 Committee Members... Scientific Committee 89 initiated its
work in 1992. Today SC89 consists of 10 members representing a broad range
of scientific disciplines, and is chaired by T. S. Tenforde, NCRP's Scientific
Vice President for Nonionizing Radiation. His areas of expertise are static
and ELF fields. Members include James E. Cleaver (UV), Arthur W. Guy (RF),
David G. Hoel (epidemiology and biostatistics), James C. Lin (RF and hyperthermia),
David H. Sliney (UV and lasers), Jan A. J. Stolwijk (ELF and RF), Richard
A. Tell (RF), Marvin C. Ziskin (ultrasound), and Thomas M. Koval (NCRP,
Sr. Staff Scientist).
Published Reports and Proceedings... NCRP reports related to
nonionizing electromagnetic fields include: Report No. 67 (1981), "Radiofrequency
Electromagnetic Fields: Properties, Quantities and Units, Biophysical Interactions,
and Measurements;" Report No. 86 (1986), "Biological Effects and Exposure
Criteria for Radiofrequency Electromagnetic Fields;" and Report No. 119
(1993), "Practical Guidance on the Evaluation of Human Exposures to Radiofrequency
Fields." Contents of Report 119 (SC89-2, Chair Richard Tell) include: quantities
and units; interactions with materials and objects; dosimetry; instruments
and measurement techniques; and hazard evaluation procedures for common
sources. Proceedings No. 8 contains papers from the 1986 NCRP meeting on
"Nonionizing Radiation and Ultrasound."
Reports in an Advanced Stage of Publication... SC89-1 report,
"Biological Effects of Static Magnetic Fields," chaired by D. D. Mahlum,
has been reviewed by Council and approved for publication. It is expected
to go to the printer in 1997. Report contents include: quantities and units;
interaction mechanisms; effects on plants; genetic, developmental, behavioral,
and physiological effects; human studies; and pacemakers and other medical
devices. The report of SC89-3, "Extremely-Low-Frequency Electric and Magnetic
Fields," chaired by W. R. Adey, is in draft form and has undergone critical
peer review; submission to Council for review and approval is anticipated
to occur in late 1996. Contents include: human exposures to ELF fields;
dosimetry; membrane-mediated signal transduction mechanisms; biological
effects in laboratory systems and human populations; mechanisms and models
of ELF field effects; and recommended exposure guidelines. Committee 89
is involved in the final preparation of Proceedings No. 16 from the 1994
NCRP Annual Meeting, "Extremely-Low-Frequency Electromagnetic Fields: Issues
in Biological Effects and Public Health."
New NCRP Report Activities Undertaken in 1995... Two new NCRP
report activities have been undertaken in 1995 - SC89-4 and SC89-5. Committee
89-4, chaired by O. Gandhi, "Modulated Radiofrequency Fields," with relevance
to wireless communication systems, will include the physical properties
and biological interactions of amplitude- and pulse-modulated RF fields;
possible human health effects; and exposure guidelines. Committee 89-5,
chaired by J. C. Lin and co-chaired by C.-K. Chou, "Biological Effects
and Exposure Criteria for Radiofrequency Electromagnetic Fields," plans
to update NCRP Report No. 86 published in 1986. The report will include
biological interactions and laboratory studies; epidemiological studies
on human health effects; and exposure guidelines.
Areas Under Discussion for New SC89 Report Activities... Areas
under discussion for new report activities include: biological interactions
and health effects of UV radiation; applications and radiation protection
aspects of UV lasers; safety of medical untrasound procedures; and dosimetry,
biological interactions, and possible health effects of fields from appliances
and other devices (e.g., VDUs, cellular telephones, police radar units,
RF heaters and sealers, microwave ovens).
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SOCIETY FOR PHYSICAL REGULATION IN BIOLOGY AND MEDICINE
COLUMN
Laura MacGinitie
The 16th Annual Meeting of the Society for Physical Regulation in Biology
and Medicine (SPRBM) will be held October 9-12, 1996, in Chicago, Illinois,
at the University of Chicago and the Midland Hotel. SPRBM council will
be meeting Wednesday prior to the meeting. The meeting will start with
registration and a mini reception on Wednesday evening. The conference
then opens with a symposium on the "Influence of Mechanical Forces on Vertebrate
Evolution and Design" featuring Drs. Biewener and Alexander. Drs. Biewener
and Alexander will discuss the evolution of locomotor strain patterns,
skeletal safety factors and bone remodeling and tendons. The symposium
will be followed by paper and poster presentations. Thursday afternoon
Dr. Samiento will present the Presidential Lecture on "Physical Forces
in Medicine, the Next Century," followed by a reception at the Fields Museum.
Friday will open with a symposium on "Osteoarthrosis: Physical Factors
in Bone and Cartilage Remodeling and Disease." Dr. Schaffler will discuss
the "Cartilage Bone Interface Force Response" and Dr. Grodzinsky will discuss
the "Cartilage Matrix Cell Response to Stress." The symposium will be followed
in the morning by papers and posters related to the symposium topic. Friday
afternoon's papers and posters will be concerned specifically with electrical
stimulation effects. On the final day of the meeting, the opening symposium
will be "Mechanisms of Cellular Mechanochemical Signal Transduction." Dr.
Johnson-Wint will discuss the "Mechanism of Force Generation by Cells."
The meeting will conclude with a full day of paper and poster presentations.
We hope to see you at the home of the deep dish pizza!
For more information, contact: SPRBM, 9650 Rockville Pike, Bethesda,
MD 20814 (Tel: 301-571-0680; Fax: 301-530-7049; Email: sprbm@faseb.org)
[Any comments or suggestions regarding topics of interest for this
column are welcome from both SPRBM and BEMS members. Please contact Laura
MacGinitie, Dept. of Engineering, Pacific Lutheran University, Tacoma,
WA 98447, (Tel: 206-535-7407; Fax: 206-536-5055; Email: macginla@plu.edu)
or Mark Otter, Department of Orthopaedics, State University of NY, T18-030
Health Science Center, Stony Brook, NY 11794-8181 (Tel: 516-444-7671; Email:
mark@bone.ortho.sunysb.edu).]
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INTERNATIONAL GRANTS FOR U.S. AND FORMER SOVIET UNION
SCIENTISTS
Through a program made possible by an award from the National Institutes
of Health (NIH), the U.S. Civilian Research and Development Foundation
(CRDF) for the Newly Independent States of the Former Soviet Union (FSU)
has announced a new competition for grants to support research projects
between U.S. scientists and their counterparts in the FSU. Current NIH
grantees and intramural scientists are invited to apply jointly with their
counterparts in the FSU. Two-year cooperative grants of up to $80,000 will
be awarded. All proposals will be evaluated through competitive peer review.
The deadline for receipt of applications is February 15, 1997.
A detailed program announcement and application instructions are available
from the U.S. Civilian Research and Development Foundation (CRDF) at http://www.crdf.inter.net;
Email: information@crdf.org; Telephone: 703-526-9720; Fax: 703-526-9721;
and from Ms. Karen Peterson, Program Officer for Russia and the NIS, Fogarty
International Center, Building 31, Room B2C11, 31 Center Drive, MSC 2220,
Bethesda, MD 20892-2220 (Telephone: 301-496-4784; Fax: 301-480-3414; Email:
p9k@cu.nih.gov).
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BACK ISSUES OF THE JOURNAL AVAILABLE
Dr. Jeannine Majde is making available copies of the BEMS Journal to anyone
who might wish to own them. She has most issues of Volumes 1-9. If interested,
please contact Jeannine at the Office of Naval Research, 800 N. Quincy
Street, Arlington, VA 22217-5660 (Tel: 703-696-4055; Fax: 703-696-1212;
Email: MAJDEJ@EXCHANGE.ONR.NAVY.MIL)
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BEMS 1996-1997 STANDING COMMITTEE CHAIRS APPOINTED
At the 65th meeting of the Board of Directors which took place on Friday,
June 14, 1996 in Victoria, B.C., Canada, BEMS President Richard Luben appointed
the Chairs of the Standing Committees. Those appointments are shown below:
Membership - Jukka Juutilainen
Nominating - Kjell Hansson Mild
Budget - Robert Liburdy
Election - Ewa Czerska
Awards - Craig Byus
Inter-Society Affairs - Gregory Lotz
URSI - Henry Lai
BES - Raphael Lee
IEEE/EMBS - Janie Blanchard
EBEA - Kjell Hansson Mild
SPRBM - Ben Greenebaum
NCRP - Richard Luben
ICNIRP - Kjell Hansson Mild
RRS - Richard Luben
Development - Paul Gailey
Publications - Janie Blanchard
Journal - Ben Greenebaum
Public Affairs - Kjell Hansson Mild
Members of Craig Byus' Awards Committee, and the date when their terms
expire include: Indira Nair (1997), Stephen Cleary (1997), Michael Repacholi
(1998), Shoogo Ueno (1998), Arthur Pilla (1999), and Bernard Veyret (1999),
plus the previous d'Arsonval Award winners for a period of five years after
receiving the Award (Carl Durney, 1998; Om Gandhi, 2000). Assisting Kjell
Hansson Mild with Public Affairs will be the four previous BEMS Presidents
- James Lin, Mary Ellen O'Connor, Om Gandhi, and Mays Swicord. Members
of Kjell Hansson Mild's Nominating Committee include Janie Blanchard and
Bernard Veyret.
Two Ad Hoc Committees and their Chairs include: (1) Education and Outreach,
Arthur Rosen, and (2) International Advisory Task Force, Stuart Allen and
Kjell Hansson Mild.
The President of the Second World Congress scheduled for 1997 is J¿rgen
Bach Andersen; BEMS representatives to the Board of Directors for the Congress
are John D'Andrea, James Lin, and Mary Ellen O'Connor.
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BEMS '96 STUDENT AWARDS GO TO LOESCHINGER AND LAZZI
At the Eighteenth Annual BEMS Meeting held in Victoria, B.C., Canada, June
1996, student awards went to one platform presentation and one poster presentation.
The platform award went to Monika Loeschinger, Section of Radiobiology
and Molecular Environmental Research, University of Tubingen, Germany,
for her presentation of the ELF-EMF-mediated changes of free intracellular
calcium which may be related to an increase in cAMP dependent PKA activity
and a decrease in c-myc mRNA expression in human skin fibroblasts. The
poster award went to Gianluca Lazzi, Department of Electrical Engineering,
University of Utah. Lazzi's research was on FTDT computation of electromagnetic
absorption in the human head for mobile telephones.
Members of the Student Awards Committee included: Chairman Lee Rosen,
Larry Anderson, Carl Durney, Om Gandhi, Indira Nair, Michael Repacholi,
Carl Sutton, and Ueno Shoogo. Students were judged on content, presentation,
ability to answer questions, and innovation or creativity.
Student awards are an important part of the BEMS Annual Meeting. The
newly appointed Awards Committee Chairman, Dr. Craig V. Byus, strongly
encourages students and their mentors to participate in the competition.
If there are any questions, he may be contacted at the Division of Biomedical
Sciences, University of California at Riverside, Riverside, CA 92521 (Tel:
909-787-4535; Email: craig.byus@ucr.edu).
Abstract of Platform Presentation
by
Monika Loeschinger
"ELF-EMF-Mediated Changes of Free Intracellular Calcium May be
Related to an Increase in cAMP
Dependent PKA Activity and a Decrease in c-myc mRNA Expression
in Human Skin Fibroblasts"
In earlier experiments, it has been demonstrated that human skin fibroblasts
(HSF) can percept and react to extremely low frequency electromagnetic
fields [ELF-EMF; 20 Hz; sinus; 6-8 mT] in distinct ways: Firstly, a long-term
exposure of ELF-EMF (21 days) reduced the proliferation rate of non-transformed
and non-activated HSF and led to an acceleration of the clearly defined
terminal differentiation process. Secondly, short-term exposures (40-60
min) could influence the intracellular free calcium ([Ca]i)-oscillation
pattern measured by means of confocal laser scanning microscopy at the
single cell level. Approximately 36% of all cells observed showed two specific
reactions: 1. In non-oscillating cells ELF-EMF-dependent [Ca]i-oscillations
with a frequency of 0,005-0,04 Hz were induced. 2. Spontaneously oscillating
cells increased the calcium spike frequencies. In order to elucidate the
ELF-EMF-induced signal transduction pathway in the present study, the protein
kinase A activity and the expression of the proto-oncogene c-myc were analyzed.
The activity of the cAMP dependent protein kinase A (PKA) was determined
by a non-radioactive detection assay (Promega). c-myc expression (RNA and
protein) was quantified by a non-radioactive Northern Blot and an ELISA
technique. All experiments were performed after a 20-60 min exposure of
normal HSF to a specific sinusoid electromagnetic field (20 Hz; 0.2 mT
and 7 mT.)
Results.....In ten independent experiments, a 60 min ELF-EMF exposure
significantly increased the activity of the cAMP-dependent protein kinase
A (Table 1). As demonstrated by the use of the PKA-specific inhibitor KT5270,
the ELF-EMF-specific signal could be inhibited (Table 1).
0.2mT 7mT 7mT+KT5270
ratio E/C+SEM 1.95+0.28 3.01+0.59 1.8+0.22
Table 1: Relative PKA activity in control (C) and ELF-EMF-exposed cells
(E) at 0.2 and 7 mT.
By means of Northern Blot analysis ELF-EMF exposure (60 min) of HSF
cells resulted in a slight reduction of the c-myc proto-oncogene expression
as compared to control conditions. However, as tested by ELISA techniques
after a 60 min exposure no significant change of c-myc expression was detected
at the protein level.
Discussion.....Regulation of proliferation and terminal differentiation
processes require an intracellular signal transduction pathway which is
possibly mediated by changes in intracellular calcium concentrations and
oscillations, protein kinase A activity as well as the modulation of the
expression of specific growth regulating proto-oncogenes. The observed
increase of the cAMP-dependent PKA and the down-regulation of the c-myc
mRNA could be an initial step of the ELF-EMF-induced growth inhibition
and accelerated terminal differentiation of the HSF cells after long-term
exposure.
Supported by the Bundesamt fur Strahlenschutz (St. Sch 4040/5) and the
Deutsche For-schungsgemeinscaft (Ha2358/1). Collaborators on the research
project included S. Thumm, H. Hammerle, and H. P. Rodemann, Eberhard-Karls-University
of Tbingen, 72076 Tbingen, Germany.
Abstract of Poster Presentation
by
Gianluca Lazzi
"FDTD Computation of Electromagnetic Absorption in the Human Head
for Mobile Telephones"
The Finite-Difference Time-Domain method has been used to calculate
the Specific Absorption Rate (SAR) distribution in the human head due to
mobile telephones. A millimeter resolution model of the human head, based
on the MRI scan of an adult male volunteer, was developed with a cell size
of 1.974 x 1.974 x 3 mm3. By scaling this model, we have also obtained
reduced size models representative of 10- and 5-year old children. In all
these models 15 tissue types were identified, and the dielectric parameters
available in the most recent literature were assigned to each of the tissues.
To perform realistic simulations the ear was squished, and the phone was
placed against the ear without any cell gap. To understand the phenomenon
of the EM coupling between the head and the telephone, several effects
were considered at both frequencies of 835 and 1900 MHz (including the
role of the antenna length l/4 and 3l/8) and the difference in tissue properties.
Especially, we have considered the effect of varying dielectric properties
of fat, bone, and cartilage since these are not as well characterized.
We have also performed simulation with a homogeneous model obtained from
the shape of the heterogeneous model and with head tilted at a typical
angle of 30°. Significant results for the 1-g average SAR are reported
in the following table, for both frequencies of 835 and 1900 MHz. The time-averaged
radiated power is assumed to be 600 mW in the case of 835 MHz, and 125
mW for the irradiation frequency of 1900 MHz. The calculated peak 1-g SARs
are given in W/kg.
It should be noted that the homogeneous model over-estimates the result
in all the cases with percentage differences that are difficult to predict.
The effect that was observed for 835 MHz, lambda/4 antenna, for models
of the 10- and 5-year old children is also very interesting. In both these
cases the peak 1-g SARs are higher than those obtained for the model of
the adult male, while the same effect was not observed at 1900 MHz. For
the models of the children, a larger in-depth absorption of EM energy produced
averaged SARs for internal tissues that are several times higher than for
the model of the adult. Some data on this important issue are summarized
in the following table, where the average SARs of some organs are given
for the 835 MHz, lambda /4 antenna. The time-averaged radiated power is
assumed to be 600 mW. Results are reported in mW/kg.
For the case of the 30° tilted head, lower 1-g average SARs than
those for the case of antenna held vertically relative to head were found
at 835 MHz for the lambda /4 antenna, while a similar effect was not observed
at 1900 MHz.
Conclusions.....As expected, the SAR distributions for 3 lambda /8 antennas
were found to be considerably smaller than those for lambda /4 antennas,
at both frequencies of 835 and 1900 MHz. Homogeneous brain-equivalent models
overestimate peak 1-g SARs for all the considered cases. Finally, higher
internal tissue SARs are obtained both at 835 and 1900 MHz for 10- and
5-year old children.
Collaborators on the research project included, C. M. Furse and O. P.
Gandhi, Department of Electrical Engineering, University of Utah, USA.
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ENGINEERING EVALUATION OF LITERATURE FOR ANSI/IEEE STANDARD
REVISION
[Presented on June 9, 1996 at a USAF Workshop on Radiofrequency Dosimetry
preceding the Eighteenth Annual BEMS meeting held in Victoria, B.C., Canada.]
The Engineering Evaluation Working Group of the IEEE SCC28 Subcommittee
4 was formed in the Summer of 1993. The mission of the Working Group was
to review and perform an engineering evaluation of papers in the database
of the Literature Surveillance Group - also of the IEEE SCC28 Subcommittee
4. Experienced and committed engineers were recruited to serve on the Working
Group. Among the 21 members, seven are from academia, eight from industry,
and six from Government.
In the Spring of 1995, eight papers were selected from the database
for a test review. Five papers were rated acceptable as engineering documentation
and three were rated inadequate. The concurrence rate among the reviewers
was very high. After the test review, the evaluation form was revised.
In November 1995, ninety-four papers were selected for the first formal
review. Among them, 43 in vitro, 37 in vivo, and 14 epidemiology papers.
Each paper was randomly distributed to two reviewers. The results were
returned before the end of April, 1996: 50 papers were rated acceptable,
18 papers were rated not acceptable, and 26 of them had a score difference
greater than two. These 26 papers were sent to a third randomly selected
reviewer (not the original two reviewers). This second cycle of review
resulted in 14 accepted papers and 12 unaccepted papers. Therefore, a total
of 64 papers (33 in vitro, 27 in vivo, four epidemiology) were deemed acceptable
in engineering reporting, and 30 unacceptable (10 papers in each category).
A copy of the evaluation form is enclosed in this Newsletter.
There are some members who need to observe deadlines and others who
are too tough or too soft on the evaluation. The concurrence rates for
the three categories were greater than 70 percent. Overall, the review
process is satisfactory and the reviewers worked very hard. I am proud
of this group. Among the reviewers, Ed Aslan was awarded for the earliest
responses and Ron Petersen for the most detailed reviews.
There are currently 1,087 papers in the SCC28 Subcommittee 4 database.
We have a lot of work to do over the next few years. We need a few more
dedicated engineers to help us. If you are interested in this challenging
task, please send an Email to me (ckc@smtplink.coh.org).
C.K. Chou, Ph.D.
City of Hope National Medical Center
Duarte, California
[IEEE SCC28, SC IV, Engineering Evaluation Working Group: Chairman
- C.K. Chou, City of Hope National Medical Center; Edward Aslan, LORAL
Microwave-Narda; Tadeusz M. Babij, Florida International University; Quirino
Balzano, Motorola; Howard Bassen, FDA; Jules Cohen, Jules Cohen & Associates,
P.C.; Kenneth R. Foster, University of Pennsylvania; Dennis E. Hadlock,
Innovative Technical Analysis Corp.; James B. Hatfield, Hatfield &
Dawson Consulting Engineers; Charles Hicks, Army, Retired; William Hurt,
USAF, Armstrong Laboratory; Niels Kuster, ETH Zurich; John Leonowich, USAF,
Armstrong Laboratory; James C. Lin, University of Illinois, Chicago; Edwin
D. Mantiply, EPA; Stewart Maurer, New York Institute of Technology; Michael
R. Moore, Oak Ridge National Laboratory; Richard G. Olsen, Naval Medical
Research Institute; John M. Osepchuk, Full Spectrum Consulting; R.C. Petersen,
Lucent Technologies; and Louis A. Williams, Jr., Louis A. Williams, Jr.
& Associates.]
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Meetings and Workshops
WORKSHOP ON THE BIOLOGICAL AND HEALTH EFFECTS OF EXTREMELY LOW FREQUENCY
(ELF) FIELDS AND RADIO FREQUENCY (INCLUDING MICROWAVE) RADIATION, WITH
AN UPDATE ON ELECTROMAGNETIC COMPATIBILITY ISSUES: October 30, 1996, Amsterdam,
The Netherlands. Organ-ized and sponsored by the Committee on Man and Radiation
(COMAR) of the Engineering in Medicine and Biology Society, IEEE.
The objective of the Workshop is to present overviews of the sources,
environmental exposure levels, bioeffects, and reported absence or presence
of human health effects, for both extremely low frequency (ELF) alternating
electric and magnetic fields, and radio frequency radiation (RFR) in the
microwave range. Also to be presented will be an update in the area of
electromagnetic compatibility (EMC), and issues related to standard setting
for EMC in medical devices in Europe. The all day conference will combine
didactic lectures, presented by experts from the United States and Europe,
with panel discussions and questions from attendees.
The Workshop is being held immediately prior to the 18th Annual International
Conference of the IEEE Engineering in Medicine and Biology Society, which
is being co-sponsored by the International Federation for Medical and Biological
Engineering in cooperation with the European Society for Engineering and
Medicine (October 31 - November 3, 1996).
Workshop participants and their contributions are shown below.
I. Introduction
-
"Comments on Related Issues in ELF Field and Radiofrequency Radiation Bioeffect
and Health Effect Studies." Dr. Martin L. Meltz, Center for Environmental
Radiation Toxicology, University of Texas Health Science Center at San
Antonio, Texas.
II. Session on ELF Fields
-
"Sources and Measurements in the European Environment." Dr. Santi Tofani,
Laboratoria Di Sanita Publica Sezione Fisica, Ivrea, Italy, and Catholic
University of Rome.
-
"In Vitro Studies." Dr. Jeffrey Saffer, Battelle, Pacific Northwest Laboratory,
Richland, Washington.
-
"In Vivo Studies." Dr. Larry Anderson, Bioelectromagnetics Section, Battelle,
Pacific Northwest Laboratory, Richland, Washington.
-
"Epidemiological Investigations Related to ELF Fields." Dr. Patricia Buffler,
Dean, School of Public Health, University of California, Berkeley, California.
III. Session on Electromagnetic Compatibility Issues
-
"Radiofrequency Interference of Patient Connected-Medical Devices." Dr.
Howard Bassen, Section for Devices and Radiological Health, Food and Drug
Administration, Rockville, Maryland.
-
"Technical Aspects and New Developments in the IEC 601-1-2 Standard for
Electromagnetic Compatibility of Medical Devices." Dr. Robert Bakker, Phillips
Medical Systems, The Netherlands.
IV. Session on Radiofrequency Radiation
-
"Sources and Levels of Exposure in the European Environment." Dr. Kjell
Hansson Mild, National Institute for Working Life, Sweden.
-
"In Vitro Studies - Cell Proliferation and Genetic Toxicology." Dr. Martin
L. Meltz, Center for Environmental Radiation Toxicology, University of
Texas Health Science Center at San Antonio, Texas.
-
"In Vitro Studies - Metabolic and Other Effects." Dr. Bernard Veyret, PIOM,
Ecole Nationale Superieure de Chimie et de Physique de Bordeaux, France.
-
"In Vivo Studies." Dr. C.K. Chou, Dept. of Radiation Research, City of
Hope National Medical Center, Duarte, California.
For more information about the Workshop and the International Conference,
and Registration Materials, Contact: Conference Secretariat, Basics International
Conference Services, University of Twente, P.O. Box 217, 7500 AE Enschede,
The Netherlands Fax: +31-53-4356770 (Email: embs96@basics.utwente.nl).
The last date for Workshop registration is October 1, 1996.
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Contact Information
The BIOELECTROMAGNETICS Society Newsletter is published and distributed
bi-monthly to all members of the Society. Information regarding the Society
may be obtained by writing to BEMS, 7519 Ridge Road, Frederick, MD 21702-3519.
Institutions and libraries may subscribe to the Newsletter at an annual
cost of $55 ($60 for overseas subscribers). The Newsletter serves
the membership and subscribers in part as a forum for the presentation
of ideas and issues related to bioelectromagnetics research. All submissions
to the Newsletter must be signed and reflect the individual views
of the authors and not official points of view of the Society or of the
institutions with which the authors are affiliated. The Society solicits
contributions to the Newsletter from its members and others in the
scientific and engineering communities. News items as well as short research
notes and book reviews are welcome. Advertisements inserted and distributed
with the Newsletter are not to be considered endorsements.
C. Jordan Evans, Editor
For Newsletter items, contact the Editor of the Newsletter.
For other Society business, contact: The Bioelectromagnetics Society, 7519
Ridge Road, Frederick, MD 21702-3519. Tel. (301) 663-4252; Fax (301) 371-8955;
E-mail 75230.1222@compuserve.com.
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